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pentobarbital will minimize the extent or result of siponimod by impacting hepatic/intestinal enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. Coadministration of siponimod by using a drug that causes moderate CYP2C9 in addition a reasonable or potent CYP3A4 inducer isn't advised.fentanyl transmucosal and pentobarbital the two increase sedati